PDRN in cosmetology. What is it, properties for the face, contraindications, price

Polydeoxyribonucleotide, or PDRN, is a revolutionary component in contemporary cosmetics. Originating from the DNA of salmon, it possesses potent skin-repairing abilities. It is a common option in anti-aging and skin restoration treatments because many professionals use it to revitalize the skin.

This treatment works by stimulating the production of collagen and elastin, which are essential for keeping the skin firm and youthful. People who undergo PDRN therapy often notice smoother, more radiant skin with fewer wrinkles and improved overall texture. It"s particularly effective for the face, where the signs of aging and environmental damage are most noticeable.

PDRN in Cosmetology	Description
What is PDRN?	PDRN (Polydeoxyribonucleotide) is a substance derived from salmon DNA, used to stimulate skin regeneration and healing.
Benefits for the Face	PDRN improves skin elasticity, reduces wrinkles, hydrates, and promotes collagen production.
Contraindications	Not recommended for pregnant women, people with cancer, or those with allergies to fish products.
Price Range	Costs can vary, typically ranging from $150 to $500 per session, depending on the clinic and region.

Polydeoxyribonucleotides – what is it

A phosphodiesterase with a low nucleus molecular weight is linked to PDRN, a linear deoxyribonucleotide polymer.

This material is utilized as a donor substrate in cosmetology. It serves as a foundation for the production of cosmetics that restore and naturally rejuvenate epithelial tissue cells. Following contact with the surface of the human skin, PDRN serves as a donor substrate to help the cell produce its own DNA molecules.

Pharmaceutical companies’ production facilities use specialized equipment to obtain polydeoxyribonucleotides.

Salmon milt tissues are chemically extracted to release the PDRN. There is DNA in this biological material, and its structure is similar to that of human leukocyte deoxyribonucleic acid. In this sense, there are no inflammatory or acute immune responses when the injection solution enters the epithelial tissue.

Mechanism of action

In the field of cosmetology, PDRN is a biochemical compound that benefits skin tissues.

The mechanism of action of linear polymers is intended to revitalize the epithelium’s cellular structure:

1. After injection, the biochemical substance is evenly distributed in the epithelial and soft tissues.
2. Polydeoxyribonucleotides trigger the process of physiological activity of adenosine receptors, which are responsible for metabolic processes in the cells of the skin.
3. By acting on the receptors, local secretory function is modeled, the nutrition of epithelial cells is improved.
4. Under conditions of improved tissue nutrition, the growth of young skin cells and the regeneration of damaged epithelium are ensured.

The premature death and necrosis of aged epithelial cells are avoided because of polydeoxyribonucleotides. It initiates the process of intracellular synthesis of its own deoxyribonucleic acid molecules, thereby dramatically speeding up skin cell division.

Indications for the use of polynucleotides in injection cosmetology

In the field of cosmetology, PDRNs are linear polymers that should be used cautiously when diseases and age-related skin changes are present.

Useful indications:

• premature aging, when the skin aging process occurs faster, and the rate of cell death does not correspond to the patient"s age;
• too slow intracellular metabolism, leading to a loss of elasticity of epithelial tissues, the formation of the effect of flabby skin (similar effects can be observed in the triangle area of ​​​​the face, around the eyes and the upper body);
• consequences of mechanical injuries, previous surgeries, burns, which led to the formation of deep scars and cicatrices (PDRN injections allow you to start the process of accelerated cell regeneration with the replacement of fibrous tissues with renewed epithelial ones);
• too dry skin requiring an additional source of moisture (the pathological condition is characterized by typical signs of peeling of the epidermis, the formation of keratinized cells);
• the need to eliminate the pathogenic activity of free radicals that can cause malignant neoplasms;
• negative reaction of the skin to ultraviolet radiation;
• the need for additional stimulation of epithelial cells to divide more quickly;
• deficiency of protein compounds that act as an intracellular matrix, provide the skin with sufficient elasticity, firmness, and also maintain its aesthetically attractive appearance;
• lack of the skin"s own nucleotides;
• mimic wrinkles on the surface of the frontal lobe of the head, around the eye sockets, the triangle of the nose, in the corners of the mouth and on the neck;
• increased pigmentation of the skin, which intensifies under the influence of sunlight;
• restoration of individual parts of the epithelium after damage by diseases of viral, bacterial or fungal genesis, the course of which was accompanied by acute or chronic inflammation.

An external examination is performed by a cosmetologist prior to writing a prescription for PDRN-based medication. Further cosmetic skin defects may be identified based on the examination results; these can be eliminated with the use of linear polymers.

Possibilities of PDRN in activating facial skin cells

In the field of cosmetics, phytodextrins (PDRNs) are biochemical compounds that function as active ingredients in products designed to repair and rejuvenate damaged epithelial cells. Destroyed nitrogen compounds that are a component of the epithelium’s DNA structure can be bound by polynucleotides.

Collagen and elastin synthesis must be increased in order to activate the skin cells in the face. Excessive concentrations of these compounds guarantee the high degree of elasticity and natural renewal of epithelial tissues.

The immunomodulatory action of PDRN-based medications encourages the quick regeneration and repair of damaged epidermal cells, which may have occurred from aging-related changes or long-term exposure to harmful substances. Skin cells are independently purified of harmful substances that hasten the aging process because of their activation.

One characteristic that sets polynucleotides apart is that they promote the faster renewal of facial epithelial cells rather than replacing the skin that has been lost due to aging. In addition, injured tissue is undergoing a difficult process of regeneration.

Safety of injections with polynucleotides

In the field of cosmetics, PDRN refers to biologically active linear polymers. The smallest units of the DNA molecule are polynucleotides due to their origin and structure.

Because of their extremely low molecular weight, they have an impact on skin cells and tissues, enhance metabolic processes, and speed up skin regeneration without being harmful. Recent research has demonstrated that DNA fragments with masses under 500 kDa, or low molecules, are not able to cause genetic diseases.

Simultaneously, there exists an opposing faction of scientists who express disapproval towards the DNA-based cell stimulation approach used for skin restoration and rejuvenation.

This kind of cosmetic product’s potential for unchecked epithelial cell growth and the development of foreign neoplasms justifies concerns about its safety.

Specialists differ in their opinions on this matter. As of right now, there isn’t a single documented clinical instance of polynucleotide-based medications leading to the emergence of a benign or malignant squamous cell tumor. Additionally unlikely are allergic reactions and adverse effects.

Contraindications

There are very few serious contraindications to using preparations based on PDRN.

Dermatologists and cosmetologists advise against using these products except in the following circumstances:

• the period of skin rehabilitation after other cosmetic procedures involving mechanical cleaning of the epidermis;
• individual intolerance to the product, which is expressed in the form of an allergic reaction with acute or moderate manifestation (may be accompanied by reddening of the skin in the area of ​​application of the product, itching, swelling, rash, irritation of the mucous membranes of the eyes);
• infectious, viral or fungal skin diseases that require preliminary therapy and complete removal of pathogenic microorganisms (for example, demodicosis, streptoderma, scabies, mycosis);
• the presence in the patient"s medical history of severe pathologies, the course of which leads to a general weakening of the immune system (tuberculosis, syphilis, AIDS, all types of oncology);
• blood diseases associated with a decrease in platelet levels and poor coagulation;
• taking antibacterial and hormonal drugs, the active components of which can reduce the cosmetic effect of the injected polynucleotides;
• acute respiratory viral infection or colds in the acute stage;
• pregnancy and breastfeeding;
• open ulcers, scratches and wounds located on the surface of the skin, the area of ​​which is exposed to products with polynucleotides.

The physician can determine if using cosmetology products based on PDRN is contraindicated based on the findings of a personalized assessment of the epithelial tissues. Also, it is advised to put off seeing a doctor if there is a recent tan on the skin’s surface or mild sunburn symptoms.

Injections with PDRN and hyaluronic acid

By injecting polynucleotide-based medications and hyaluronic acid, you can:

• restore stable hydration of the skin;
• make epithelial tissues more elastic and elastic;
• smooth out pronounced epidermal and dermal wrinkles that occur due to age-related changes in the skin;
• ensure even faster regeneration of damaged tissues;
• reduce the diameter of enlarged pores;
• reduce the severity of rosacea of ​​epidermal tissues.

Drugs may need to be taken simultaneously if there are severe skin injuries, mechanical tissue damage, deep wrinkles, a lack of elastin, or if the epithelium needs to regenerate quickly following surgery.

Efficiency of rejuvenating injections with polynucleotides

When injected into epithelial tissues, cosmetology products based on PDRN have the following effects:

• stimulate the process of repair and regeneration of cells;
• reduce the period of re-epithelialization of the skin;
• provide rapid uniform distribution of granulation tissues around open wounds and trophic ulcers;
• enhance metabolic processes that occur in the intracellular space;
• promote uniform distribution of moisture within epithelial tissues;
• have a complex anti-inflammatory effect;
• reduce the concentration of the cytokine TNF-a substance, which accumulates in the tissues of the skin, and then causes local inflammatory processes;
• protects the epidermis from the harmful effects of ultraviolet radiation of types A and B;
• neutralizes free radicals that have entered the epithelial cells due to the negative impact of environmental factors;
• stimulates skin ferroblasts to more active synthesis of elastin, extracellular protein matrix and collagen.

The primary medicinal and aesthetic impact of products based on polynucleotides is the saturation of epithelial tissue cells with the tiniest possible DNA particles. The process of safely constructing young epidermal cells is initiated, but there is no acute immune reaction because of the low molecular weight of PDRN.

The skin would continue to deteriorate with age if injectable rejuvenation products weren’t used.

Polydeoxyribonucleotide, or PDRN, is a well-liked component in contemporary cosmetics because of its restorative qualities. By promoting cell repair, it enhances skin elasticity, minimizes wrinkles, and fosters general rejuvenation. It is primarily used in facial treatments and is especially useful for skin healing and anti-aging. PDRN treatments do have some contraindications, though, such as pregnancy, allergies, and specific skin conditions, just like any cosmetic procedure. Due to their increasing popularity and effectiveness, PDRN-based treatments can range in price depending on the clinic and location, but generally speaking, they are more expensive.

PDRN-based products

Polynucleotide-based cosmetic products are used for biorevitalization and rejuvenation, as well as skin augmentation and epithelial tissue restoration around the eyes.

For skin boosterization

It is possible to use the medication TwAc 2 to produce the skin boosterization effect.0. This is a liquid gel that is sterile and is applied topically. has a long-chain nucleotide in it. replenishes thinning and aged skin. The application of this product is recommended for the hands, face, neck, and décolleté.

The medication for skin boosterization, TwAc 3.0, is determined by the cosmetologist. The product includes highly purified hyaluronic acid in addition to PDRN.

It guarantees the regeneration of epithelial tissues, fortifies the muscle matrix, preserves skin suppleness, and also incites the defensive mechanisms of local immunity. It is made as a transparent, viscous gel and is contained in a sterile, 3-milliliter syringe.

For the skin around the eyes

Use the medication TwAc Eyes to repair the skin surrounding your eyes. This is a long-chain polynucleotide solution that is liquid and sterile. It is completely transparent, hypoallergenic, odorless, and toxin-free. It is meant to be used to address skin alterations brought on by aging that manifest around the eyes.

One milliliter (1 ml) sterile disposable syringe holding the mesotherapeutic solution. Both the upper and lower eyelids are injected with the medication.

For biorevitalization

Based on PDRN, the following products are advised for use in the cosmetology procedure of biorevitalization:

• IAL-system;
• Filorga M-HA10;
• Princess Rich;
• Biofactor;
• Repleri.

Every product listed above has the same characteristics. They have hyaluronic acid and polynucleotides in them.

Products for biorevitalization come in sterile solution form and are packaged in single-use syringes that hold one to three milliliters. designed to nourish and moisturize skin, reduce signs of increased pigmentation, and smooth wrinkles and bags under the eyes.

For skin rejuvenation

Injectable products based on PDRN are used to achieve the effect of skin rejuvenation. These products come in sterile solution form and contain hyaluronic acid.

These goods are as follows:

• Newest – designed to correct age-related changes in epithelial tissues, improves skin tone, eliminates expression wrinkles, promotes epidermis moisturizing;
• Plinest Fast – used to prevent aging of young skin that is exposed to negative environmental factors;
• Plinest – the intended purpose of this product is to combat deep wrinkles, scars and cicatrices, restore tissue elasticity (intended for old skin);
• Ialest – has a rejuvenating effect, strengthens epithelial tissues and local immunity, and also saturates them with an additional amount of hyaluronic acid;
• Plinest Body – this product is intended for rejuvenation of all parts of the body.

The high cosmetic effect and safety of each of the aforementioned polynucleotide-based products have been demonstrated. The extended outcome is valid for the ensuing 12 months.

Preparation and procedure

Products based on PDRN can be injected without complicated preparation. You need to shower and properly wash the areas of your body that will be subjected to cosmetic effects the day of the procedure. Alcohol consumption is prohibited for 24 hours prior to the injections. The final cigarette must be smoked no later than forty minutes prior to seeing a physician.

The actual rejuvenation process is performed as follows:

1. The patient sits down in a chair or lies down on a couch.
2. The doctor performs antiseptic treatment of the skin.
3. The doctor takes out a disposable syringe with a mesotherapeutic agent and injects the solution into the body tissue.
4. The area of ​​injection of the drug is re-treated with an antiseptic.

The patient is advised to avoid hypothermia for seven days following the procedure, as well as using hormonal, anti-inflammatory, and antibacterial medications, as well as sauna visits.

What is the difference between biorevitalization with hyaluronic acid and polynucleotides in cosmetology

The following are the primary distinctions between the polynucleotide and hyaluronic acid biorevitalization process, which are listed in the table below.

Main factors of difference	Hyaluronic acid	Polynucleotide
Mechanism of action	Provides deep hydration of the skin. Stimulates the work of fibroblasts to synthesize their own elastin and collagen.	Stimulates the process of intracellular metabolism and restores the youth of epithelial tissues due to the effect of DNA with a low molecular weight.
Application areas	All parts of the body, but with precautions in the periorbital area.	On the face, neck, décolleté, scalp, as well as on other parts of the body.
Manifestation of the first effect	The cosmetic effect occurs instantly. Over the next 7 days, the properties of hyaluronic acid are enhanced.	More days are required to show a positive effect, but the result obtained lasts up to 1 year.
Minimum number of procedures	From 3 to 5	From 3 to 5

Combination of PDRN with other procedures

It is not advised to use other cosmetic procedures while the skin is being rejuvenated and restored with the aid of PDRN-based preparations. Observing this restriction is required.

Price of PDRN

Products based on polynucleotides range in price from 3600 to 7200 rubles on average. Depending on the drug’s dosage and intended use. Buying mesotherapeutic gels and solutions from authorized vendors is advised.

In the field of cosmetics, PDRN is a cutting-edge technique that initiates an autonomous cell division program to restore damaged and aging epithelial tissues quickly.

The tiniest DNA fragments found in salmon fish milk are utilized for this. These substances’ low molecular weight prevents allergic reactions, immunological responses, and intoxication symptoms. The cosmetic product replenishes the skin’s nutrition and elasticity.

PDRN’s potent skin-rejuvenating qualities have made it more and more popular in the cosmetology field. It promotes a healthier complexion, lessens wrinkles, and increases skin elasticity. Many find that it works well to give them a youthful glow without requiring invasive procedures.

Like any therapy, PDRN isn’t appropriate for everyone, though. To make sure it’s the best decision for your skin, it’s critical to weigh the possible risks and speak with an expert. Recognizing the contraindications can assist you in preventing unfavorable side effects.

The number of sessions needed and the clinic can affect how much PDRN treatments cost. Even though it might seem pricey, many people find that the long-lasting effects make the investment worthwhile. Make sure to look into your options and select a clinic that fits your budget and needs.

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